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Target intelligence / Profile preview
Glycosylphosphatidylinositol biosynthesis protein Gwt1 (Gwt1)
- Target
- Gwt1
- Molecular classification
- Enzyme, Acyltransferase
01
Overview
Glycosylphosphatidylinositol biosynthesis protein Gwt1 (Gwt1) is an essential membrane-bound enzyme involved in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors. These anchors are critical post-translational modifications that tether proteins to the cell surface in eukaryotes, playing a vital role in cell wall integrity and protein localization, especially in fungi. Gwt1 functions as an acyltransferase, specifically catalyzing the acylation of the inositol ring of glucosaminyl-phosphatidylinositol (GlcN-PI). It is a validated target for novel antifungals like Manogepix.
02
Mechanism of action
Inhibition of Gwt1 activity by competitive binding to the palmitoyl-CoA binding site.
03
Biological functions
Glycosylphosphatidylinositol anchor synthesisProtein modificationCell wall biogenesis (fungi)
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effectsDrug resistance
06
Interacting drugs
Manogepix
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