Glycosyltransferase 1 domain-containing protein 1 (GLT1D1)

Glycosyltransferase 1 domain-containing protein 1 (GLT1D1) is a cytosolic enzyme responsible for the transfer of glycosyl groups—including galactose, N-acetylglucosamine, and sialic acid—to substrate proteins, forming glycosidic bonds required for proper protein glycosylation[1][4][5][10]. Its activity plays a significant role in immune regulation, with evidence supporting involvement in the glycosylation and stabilization of PD-L1, an immune checkpoint molecule, contributing to cancer cell immunosuppression and correlating with poor prognosis in certain malignancies[3][9]. Although not yet a widely targeted therapeutic protein, GLT1D1's enzymatic function and association with disease processes make it relevant for continued research in oncology and immunology. Alternative names include FLJ31978 and Q96MS3, and it is catalogued on chromosome 12 (human), with protein sequences available in major genetic repositories[4][9][10].

Other names

Glycosyltransferase 1 domain containing 1GLT1D1FLJ31978Q96MS3 (UniProt accession)GC12P127863, GC12P129337, GC12P126322 (GeneCards IDs)

Inhibition or modulation of GLT1D1 could alter glycosylation patterns on immune checkpoint molecules (such as PD-L1), potentially reversing tumor immune evasion and impacting tumor immunogenicity. Targeting glycosyltransferase activity might influence mucosal immunity and host-pathogen interactions.