Glycylpeptide-N-tetradecanoyltransferase 2

N-myristoyltransferase 2 (NMT2) is an enzyme that catalyzes the covalent attachment of myristic acid to the N-terminal glycine residue of substrate proteins. This modification, known as N-terminal myristoylation, is crucial for regulating protein function and localization. NMT2 plays roles in cell growth, apoptosis regulation, cardiac remodeling, and potentially tumor suppression. It has emerged as a potential therapeutic target for cancer and cardiac diseases, with inhibitors under investigation for their ability to disrupt aberrant signaling pathways dependent on protein lipidation modifications like myristoylation.

Other names

N-myristoyltransferase 2NMT2

Inhibition of N-myristoylation