Glyoxalase domain-containing protein 5 (GLOD5)

Glyoxalase domain-containing protein 5 is a member of the glyoxalase gene family, characterized by its glyoxalase domain—structurally a βαβββ motif crucial for the coordination of divalent metal ions. The protein is encoded by the GLOD5 gene located on chromosome X (Xp11.23); several alternatively spliced variants are known, with predicted mitochondrial localization due to a targeting sequence. Expression is highest in the gastrointestinal tract. Unlike other glyoxalase family members (such as GLO1), the precise enzymatic activity, substrate specificity, and physiological role of GLOD5 remain unknown—as does its relevance to human disease or therapeutics. No knockout models, drug interactions, or mechanisms of action have been described, and its utility as a biomarker or safety concern in clinical use is unsupported. Further experimental studies are needed to elucidate its potential function and disease involvement.

Other names

GLOD5Glyoxalase domain containing 5Glyoxalase domain-containing protein 5A6NK44 (UniProt)ENSG00000171433 (Ensembl)392465 (NCBI Gene)