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Target intelligence / Profile preview
Glypican-2 (GPC2)
- Target
- GPC2
- Molecular classification
- Heparan sulfate proteoglycan, Glypican family member, Cell surface protein
01
Overview
Glypican-2 (GPC2) is a cell surface heparan sulfate proteoglycan involved in developmental processes, particularly in the nervous system. It functions in cell adhesion, axon guidance, and as a co-receptor for several signaling pathways, including Wnt, Hedgehog, FGF, and BMP signaling. GPC2 exhibits restricted expression in normal adult tissues but is highly overexpressed in several cancers, including neuroblastoma, medulloblastoma, retinoblastoma, small-cell lung cancer and prostate cancer, making it an attractive target for cancer immunotherapy.
- Other names
- Cerebroglycan
02
Mechanism of action
Immunotherapies (antibodies, CAR-T cells) targeting GPC2
03
Biological functions
Cell adhesionAxon growth and guidanceNeuronal migrationNeurite outgrowthCo-receptor for Wnt proteinsCo-receptor for Hedgehog proteinsCo-receptor for Fibroblast growth factors (FGFs)Co-receptor for Bone morphogenetic proteins (BMPs)
04
Disease associations
NeuroblastomaMedulloblastomaRetinoblastomaSmall-cell lung cancerProstate cancerPancreatic ductal adenocarcinoma
05
Safety considerations
Potential for off-target effects in tissues with low GPC2 expressionRisk of on-target, off-tumor toxicityImmunogenicity of therapeutic antibodies
06
Biomarkers
GPC2 expression level in tumor tissue
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