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GM1 ganglioside receptor
- Molecular classification
- Glycosphingolipid, Ganglioside, Receptor
01
Overview
GM1 ganglioside is a glycosphingolipid that functions as a receptor involved in neuronal plasticity, repair, neuroregeneration, and signal transduction. It acts as a high-affinity receptor for cholera toxin and certain viruses, and is implicated in various neurological and autoimmune disorders. It modulates membrane organization and influences properties of membrane enzymes and receptors. Exogenous administration has shown therapeutic effects in neurodegenerative disease models.
02
Mechanism of action
Modulation of membrane organization and influencing properties of membrane enzymes and receptors, amplification of neurotrophic factor responses, high-affinity binding site for toxins and viruses.
03
Biological functions
Neuronal plasticityNeuroregenerationNeuroprotectionSignal transductionCell differentiationNeuritogenesisSynaptic function
04
Disease associations
GM1 gangliosidosisGuillain–Barré syndrome (GBS)Multifocal motor neuropathy (MMN)DementiaLupusNeurodegenerative disease
05
Safety considerations
Autoantibody formationPotential for exacerbating autoimmune conditionsToxin-mediated cell entry
06
Interacting drugs
Cholera toxin
1 more in the full profile.
07
Biomarkers
GM1 ganglioside levelsAnti-GM1 antibodies
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