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GM3 (Neu5Gc) ganglioside
- Molecular classification
- Glycosphingolipid, Ganglioside
01
Overview
GM3 (Neu5Gc) ganglioside is a glycosphingolipid found on the surface of cells, particularly enriched in certain cancers. It consists of a ceramide lipid anchor, a lactosylceramide core, and one N-glycolylneuraminic acid (Neu5Gc) residue. Humans lack the enzyme to synthesize Neu5Gc, making it a tumor-associated antigen and a target for cancer immunotherapy.
- Other names
- NeuGca2–3Galβ1–4Glcβ1–1′CeramideN-glycolyl-monosialodihexosylgangliosideGanglioside GM3(NeuGC)
02
Mechanism of action
Targeting with monoclonal antibodies or CAR-T cells to induce cell death in tumor cells expressing GM3(Neu5Gc).
03
Biological functions
Cell signalingModulation of membrane protein functionCell proliferationCell differentiationCell adhesionCell migrationApoptosis
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects in tissues with low levels of GM3(Neu5Gc) expression due to dietary incorporation.Immunogenicity of Neu5Gc in humans.
06
Biomarkers
GM3(Neu5Gc) expression level in tumor tissue
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