GNAS antisense RNA 1 (GNAS-AS1)

GNAS antisense RNA 1 (GNAS-AS1) is a long non-coding RNA (lncRNA) transcribed from the GNAS gene locus on chromosome 20q13.3. It is a paternally-imprinted and antisense transcript to the GNAS gene, which encodes the alpha subunit of the stimulatory G protein. GNAS-AS1 influences the expression of the GNAS complex locus, is involved in the regulation of multiple cellular functions including cell proliferation, apoptosis, and epithelial-mesenchymal transition, and is implicated in the development of a variety of diseases such as cancer (breast, lung, and pituitary), pseudohypoparathyroidism type Ib, McCune-Albright syndrome, and metabolic disorders. GNAS-AS1 exerts its effects primarily through interactions with microRNAs (such as miR-433-3p) and other gene regulatory mechanisms. It is not a classical drug target such as a receptor, enzyme, or transporter, but has significance as a biomarker and regulator of disease pathogenesis.

Other names

GNAS-ASGNAS1ASNCRNA00075NESP-ASNESPASSANGGNASASnon-protein coding RNA 75

Not a direct drug target; functions by regulating microRNAs (e.g., miR-433-3p), gene expression, and signaling axes such as miR-433-3p/GATA3 and miR-433-3p/Rab3A