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Goblet Cell

Molecular classification: Epithelial cell, Secretory cell

Overview

Goblet cells are specialized, unicellular epithelial cells primarily responsible for the synthesis and secretion of mucus. They are named for their distinctive goblet- or cup-like shape. Their primary function is to produce gel-forming mucins, high-molecular-weight glycoproteins, which combine with water to form mucus that protects epithelial surfaces from mechanical damage, pathogens, toxins, and dehydration and lubricates passageways.

Biological functions

Mucus productionEpithelial protectionLubricationTrapping of inhaled particles

Disease associations

AsthmaChronic bronchitisInflammatory bowel disease (IBD)Ulcerative colitisMucus hypersecretion

Safety considerations

Goblet cell hyperplasia leading to excessive mucus productionChanges in goblet cell density/functionality in gastrointestinal disorders

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