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Target intelligence / Profile preview
Golgi alpha-mannosidase II (GMII)
- Target
- GMII
- Molecular classification
- Enzyme, Glycosyl hydrolase, Type II transmembrane protein
01
Overview
Golgi alpha-mannosidase II (GMII) is a key glycosyl hydrolase enzyme involved in the N-linked glycosylation pathway. It catalyzes the removal of two mannosyl linkages from GlcNAcMan\(_5\)GlcNAc\(_2\), a committed step in complex N-glycan synthesis. GMII is essential for the maturation of N-glycans on glycoproteins within the Golgi apparatus. Inhibition of GMII has shown promise as a therapeutic strategy against certain cancers. Mutations in the MAN2A1 gene, encoding GMII, can disrupt normal glycoprotein processing and, in mice, lead to systemic autoimmune disease phenotypes.
- Other names
- AMan IIGOLIM7MANA2MANII
02
Mechanism of action
Inhibition of Golgi alpha-mannosidase II, preventing the processing of N-glycans and disrupting glycoprotein maturation.
03
Biological functions
N-linked glycosylationGlycoprotein processingComplex N-glycan synthesisProtein foldingHydrolysis
04
Disease associations
CancerAutoimmune disease (mouse model)
05
Interacting drugs
Swainsonine
1 more in the full profile.
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