Golgi apparatus membrane protein TVP23 homolog B (TVP23B)

Golgi apparatus membrane protein TVP23 homolog B (TVP23B) is a 205-amino-acid, multipass transmembrane protein, with a predicted molecular mass of ~23 kDa and an isoelectric point of 8.62[3]. It is predicted to localize primarily to the Golgi membrane and cytoplasm, and participates in vesicle-mediated transport and protein secretion, contributing to cellular homeostasis and response to metabolic stress, especially in the context of retinal cells[1][4]. The protein belongs to the FAM18/TVP23 superfamily and contains the DUF846 domain, a feature conserved across diverse eukaryotic species. TVP23B is expressed in nearly all tissues and cell types, without tissue-specific restriction, including heightened expression in bladder and other tissues[3][5]. Current evidence does not indicate TVP23B as a direct therapeutic target (such as a receptor, enzyme, ion channel, or transporter), nor is it recognized as the target of any approved drugs or clear disease biomarkers. However, gene associations with Charcot-Marie-Tooth disease and speculative correlations with diabetic retinopathy suggest potential relevance in disease, warranting further investigation into its roles and possible therapeutic or diagnostic value[1][4]. TVP23B's molecular function aligns with essential intracellular trafficking and protein sorting, underscoring its contribution to core cellular processes rather than direct druggability.

Other names

FAM18BFAM18B1CGI-148NPD008YDR084Ctrans-golgi network vesicle protein 23 homolog B (S. cerevisiae)