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Golgi apparatus membrane protein TVP23 homolog C (TVP23C)
- Target
- TVP23C
- Molecular classification
- Other: TVP23C belongs to the class of “Golgi membrane proteins” and contains domain of unknown function 846 (DUF846)., It is a “transmembrane protein” with 4 transmembrane helical segments., It does not belong to typical classes such as “Enzyme”, “Receptor”, “Transporter”, “Transcription factor”, “Ion channel”.
01
Overview
TVP23C, also named Golgi apparatus membrane protein TVP23 homolog C, is a small transmembrane protein encoded by the TVP23C gene on chromosome 17. It is part of a conserved family found in vertebrates and yeast, defined by the domain of unknown function DUF846, and is believed to participate in membrane trafficking within the trans-Golgi network and endosomal system[1][6]. TVP23C is structurally composed of four alpha helical transmembrane domains and is highly homologous to TVP23A and TVP23B, sharing more than 50% amino acid identity[1]. While TVP23A/B function is better characterized (retrograde trafficking in Golgi), the specific functions and disease roles of TVP23C remain poorly described, with no current evidence for being a therapeutic target or disease marker[1][6][5]. TVP23C may undergo fusion with other genes such as CDRT4 in certain tumors, but the functional and clinical significance of these events is not known[2].
- Other names
- TVP23CFAM18B2Nbla10383MGC8763Golgi apparatus membrane protein TVP23 homolog CFamily with sequence similarity 18, member B2Protein FAM18B2
02
Biological functions
Inferred to be involved in vesicular transport, likely in retrograde trafficking from endosomes to the Golgi apparatus, based on homology with TVP23A and TVP23B.No well-defined role in signal transduction, apoptosis, or other major cellular processes has been described.For TVP23A/B/C, the general function is maintenance and trafficking within the Golgi/endosomal system.
03
Disease associations
Other: There is currently no association between TVP23C and specific diseases such as cancer, inflammation, neurodegeneration, infection, or cardiovascular disease.Rare fusion events involving TVP23C have been detected (e.g., TVP23C-CDRT4), but clinical implications, if any, remain unknown.
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