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Target intelligence / Profile preview
Golgi-associated kinase 1A (GASK1A)
- Target
- GASK1A
- Molecular classification
- Kinase (protein kinase), FAM198 family
01
Overview
Golgi-associated kinase 1A (GASK1A) is a protein kinase active within the Golgi apparatus and endoplasmic reticulum, encoded by the GASK1A gene. It belongs to the FAM198 protein family and is believed to function in phosphorylation and possibly the cellular secretory pathway; its physiological role remains incompletely characterized, with evidence suggesting involvement in muscular dystrophy-dystroglycanopathy. While it is a broadly expressed intracellular kinase, there are no current therapeutic agents or characterized molecular mechanisms targeting this gene[1][2][3][4][5][14].
- Other names
- GASK1AC3orf41FAM198ADKFZP434B172Protein FAM198AFamily with sequence similarity 198 member A
02
Biological functions
Phosphorylation (predicted/upstream activity)Putatively implicated in secretion and Golgi function
03
Disease associations
Muscular dystrophy-dystroglycanopathy, type C12Congenital muscular dystrophy-dystroglycanopathy type A12
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