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Target intelligence / Profile preview
Golgi-associated plant pathogenesis-related protein 1 (GLIPR2)
- Target
- GLIPR2
- Molecular classification
- Other (multifunctional Golgi membrane-associated protein, member of the plant pathogenesis-related protein family, CAP superfamily)
01
Overview
Golgi-associated plant pathogenesis-related protein 1 (GLIPR2, also known as GAPR1) is a multifunctional, Golgi-localized protein widely expressed in human tissues. It is implicated in the regulation of autophagy, protein dimerization, ERK signaling, cell migration, EMT, and immune responses. GLIPR2 functions as a tumor suppressor, with lower expression observed in multiple cancers, particularly lung adenocarcinoma, where higher levels associate with better prognosis and enhanced sensitivity to radiotherapy. It has demonstrated potential as a diagnostic, prognostic, and predictive biomarker, and may serve as a therapeutic target in oncology, although clinical drug development targeting GLIPR2 per se has not been reported to date[1][2].
- Other names
- Glioma pathogenesis-related protein 2GAPR1GAPR-1Golgi-associated PR-1 proteinC9orf1917kD fetal brain protein
02
Mechanism of action
Induction of autophagy via interaction with beclin 1; Modulation of malignant cell phenotypes, migration, invasion, and treatment sensitivity
03
Biological functions
Regulation of autophagyProtein homodimerizationPositive regulation of ERK1/2 cascadeRegulation of cell migration and epithelial-to-mesenchymal transition (EMT)Involvement in immune cell infiltration and response
04
Disease associations
Cancer (especially lung adenocarcinoma and other malignancies)Biomarker for pancreatic ductal adenocarcinomaPossible association with intracranial vasospasm and necatoriasis
05
Safety considerations
No direct clinical therapeutic safety concerns or challenges are established, as most evidence is preclinical or biomarker-focused
06
Interacting drugs
Tat-beclin 1 peptide (induces autophagy, reported in research context)
07
Biomarkers
Prognostic and diagnostic biomarker (notably in lung adenocarcinoma and possibly other cancers)Predictive marker for radiotherapy response in lung adenocarcinomaBiomarker for pancreatic cancer
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