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Target intelligence / Profile preview
Golgi-associated RAB2 interactor protein 1A (GARIN1A)
- Target
- GARIN1A
- Molecular classification
- Other (non-receptor, non-enzyme, non-ion channel), Vesicle-trafficking effector, Golgi-associated protein
01
Overview
Golgi-associated RAB2 interactor protein 1A is a member of the GARIN/FAM71 protein family, characterized by a RAB2-binding domain that enables interaction with RAB2A/B small GTPases. It is predominantly expressed in the testis and localizes to the Golgi apparatus, where it contributes to vesicle trafficking required for acrosome biogenesis and normal sperm head morphology. Functional knockouts in animal models indicate a critical role in male fertility, but it is not a recognized therapeutic target and its nomenclature is frequently confounded with related family members
- Other names
- GARIN1AFAM137BFAM71F2GARIGolgi-associated RAB2B interactor
02
Biological functions
Acrosome biogenesisSperm head morphogenesisMembrane traffickingVesicle anchoring/processing in the Golgi apparatus
03
Disease associations
Male infertility (Animal genetic studies)Other
04
Biomarkers
Highly expressed in testis, may be a candidate biomarker for testicular function or defects
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