Golgi-associated RAB2 interactor protein 1B (GARIN1B)

Golgi-associated RAB2 interactor protein 1B (GARIN1B) is a protein encoded by the GARIN1B gene. It functions as a RAB2B effector protein critical for proper acrosome formation and normal male fertility. GARIN1B acts in the Golgi apparatus and is involved in acrosome assembly, likely functioning to regulate vesicle trafficking between the Golgi and the acrosome during sperm development. Disruption of GARIN1B causes abnormal vesicle trafficking leading to impaired acrosome formation and male infertility. This protein has no established role as a classical drug target (such as a receptor or enzyme) and is not currently associated with any known interacting drugs or clinical biomarker use[1][5][6]. - **Note**: Based on current knowledge, GARIN1B is not a classical therapeutic target or receptor but is more relevant for fundamental reproductive biology and as a possible gene linked to genetic forms of male infertility[1][5][6]. - **If used as a target in the context of drug discovery or therapy, this would be considered incorrect at present.** - There is no evidence of involvement in cancer, inflammation, neurological disease, or direct druggability. **Summary of validation**: - The entry is scientifically accurate as a protein/gene but incorrect as a therapeutic target. - There is significant alias redundancy, and the molecule is not a canonical target in pharmacology or medicine. - Multiple aliases refer to the same gene, but none correspond to a protein traditionally classified as a drug target (e.g., receptor, enzyme)[1][5][6].

Other names

FAM137AFAM71F1NYD-SP18GARI-L1GARIL1Testis development protein NYD-SP18Golgi-associated RAB2B interactor like 1testes development-related NYD-SP18testicular tissue protein Li 67