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Target intelligence / Profile preview
Golgi-associated RAB2 interactor protein 2 (GARIN2)
- Target
- GARIN2
- Molecular classification
- Other (RAB2 effector protein, vesicle trafficking/regulatory protein)
01
Overview
Golgi-associated RAB2 interactor protein 2 (GARIN2) is a member of the GARIN/FAM71 protein family, which consists of multiple related genes predominantly expressed in the testis[1][2][3]. GARIN2 and other GARIN family members possess a conserved RAB2-binding domain and can interact with RAB2A and RAB2B, small GTPases involved in membrane trafficking between the Golgi apparatus and other organelles in spermiogenesis[1][2]. In mice, knockout of GARIN2 leads to abnormal sperm head morphogenesis but does not significantly impair male fertility, indicating an important but not absolutely essential role in sperm development[1][2]. GARIN2 is predicted to participate in membrane vesicle transport and morphological maturation of sperm cells, alongside other related proteins. To date, there are no known drugs targeting this protein, and it is not recognized as a standard therapeutic target in human disease[1][2][3].
- Other names
- C14orf54FAM71DGARI-L2GARI-L1Golgi associated RAB2 interactor family member 2protein FAM71D
02
Biological functions
Sperm head morphogenesisCell morphogenesisMembrane protein traffickingVesicle anchoring/processingFlagellated sperm motility (predicted)Penetration of zona pellucida (predicted)
03
Disease associations
Male infertility (animal model)Reproductive defects (sperm morphological abnormalities)
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