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Target intelligence / Profile preview
Golgi-associated RAB2 interactor protein 4 (GARIN4)
- Target
- GARIN4
- Molecular classification
- Other (Rab-binding Golgi protein)
01
Overview
Golgi-associated RAB2 interactor protein 4 (GARIN4) is a cytoplasmic protein encoded by the GARIN4 gene. It contains an N-terminal Rab-binding domain and interacts specifically with the small GTPase Rab2B, playing a crucial role in maintaining the compacted architecture and integrity of the Golgi body. Knockdown of GARIN4 disrupts Golgi structure, reflecting its essential function in intracellular vesicular trafficking and organelle maintenance. GARIN4 is a member of the FAM71 family and does not belong to recognized therapeutic target classes like receptors, enzymes, or ion channels. There are currently no known drugs or biomarkers associated with GARIN4, and it is not established as a therapeutic drug target[1][3][5][8][11].
- Other names
- FAM71AGARI-L4GARI-like 4FLJ32796GARIL4Golgi-associated Rab2B interactor-like 4Family with sequence similarity 71 member AProtein FAM71ATestis secretory sperm-binding protein Li 209a
02
Biological functions
Maintenance of Golgi apparatus structureInteraction with Rab2B small GTPase
03
Disease associations
Bardet-Biedl syndrome 12Occupational asthmaOther (no established direct mechanistic disease roles)
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