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Golgi integral membrane protein 4 (GOLIM4)
- Target
- GOLIM4
- Molecular classification
- Other (Golgi-localized scaffold/transporter protein; not a receptor, enzyme, transporter, or GPCR)
01
Overview
Golgi integral membrane protein 4 (GOLIM4) is a type II transmembrane protein localized primarily to the Golgi apparatus, where it is involved in sorting and transport of proteins from the endoplasmic reticulum through the Golgi to other cellular locations. It acts as a scaffold protein facilitating the formation of secretory vesicles by interacting with other Golgi proteins such as ATP2C1 and GOLPH3. Its dysfunction is linked to rare diseases including congenital disorders of glycosylation and distal hereditary motor neuronopathies.
- Other names
- Golgi phosphoprotein 4GOLPH4Golgi phosphoprotein of 130 kDaGPP130P138GIMPCGolgi integral membrane protein, cis130 kDa Golgi-localized phosphoproteincis Golgi-localized calcium-binding proteintype II Golgi membrane protein
02
Biological functions
Vesicle-mediated transportEndosome to Golgi protein traffickingBiogenesis of secretory vesiclesProtein processing and sorting in Golgi apparatus
03
Disease associations
Congenital disorder of glycosylation (type In)Distal hereditary motor neuronopathy, Autosomal recessive 3
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