Golgi pH regulator B (GPR89B)

Golgi pH regulator B (GPR89B) is a membrane protein encoded by the GPR89B gene on chromosome 1 that functions primarily as a voltage-gated anion channel within the Golgi apparatus, transferring ions such as iodide, chloride, bromide, and fluoride to support Golgi acidification and intracellular pH regulation[4][1][3]. It is also known by a range of aliases, partly reflecting its unexplored or orphan receptor status in the GPCR family, though its main activity is now considered anion transport rather than traditional GPCR ligand signaling[3][4][6]. GPR89B plays a role in lymphocyte development and is implicated in rare immunodeficiency syndromes, chromosomal disorders, and a growing set of cancers, especially as part of the broader GPCR family that is increasingly investigated for tumor targeting and personalized medicine applications[1][2][3][4][8]. No drugs are currently approved that specifically target GPR89B, but its molecular features suggest potential tractability for small molecules or antibody drug conjugates, though more functional and phenotypic clarity is needed before clinical application[8].

Other names

G protein-coupled receptor 89BGPHRGPR89GPR89CLINC02804SH120UNQ192Golgi pH regulator BGolgi pH regulator AGolgi pH regulator CHSPC201Protein GPR89Bputative MAPK-activating protein PM01putative NF-kappa-B-activating protein 90

Not specifically described for GPR89B as a drug target - As a family: small molecule/peptide ligand binding to modulate anion channel or signal transduction (by analogy to other GPCRs and anion channels)