Golgi phosphoprotein 3 (GOLPH3)

Golgi phosphoprotein 3 (GOLPH3) is a highly conserved peripheral membrane protein predominantly localized to the trans-Golgi network[1][2][3]. GOLPH3 binds phosphatidylinositol 4-phosphate (PI4P) and links the Golgi to the actin cytoskeleton through MYO18A, facilitating vesicular trafficking toward the plasma membrane[1]. GOLPH3 regulates the structure and ribbon morphology of the Golgi apparatus, and its activity is modulated by growth factor signaling and in response to DNA damage (via DNA-PK-mediated phosphorylation)[1][2]. Overexpression or gene amplification of GOLPH3 is identified in multiple human cancers and correlates with poor prognosis[2][4]. Its functions include maintaining Golgi architecture, supporting cell survival post-DNA damage, and promoting cell proliferation through modulation of mTOR signaling[4]. GOLPH3 is under investigation as a therapeutic target and a potential biomarker for cancer therapy response[1][2][4].

Other names

GPP34MIDASGOPP1Vps74 (yeast homolog)Coat protein GPP34Mitochondrial DNA absence factorGolgi peripheral membrane protein 1 (34 kDa)

Not directly established for approved drugs; experimental strategies under investigation include interfering with GOLPH3-dependent trafficking pathways or GOLPH3 overexpression to sensitize/treat cancers