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Target intelligence / Profile preview
Golgi SNAP receptor complex member 1 (GOSR1)
- Target
- GOSR1
- Molecular classification
- t-SNARE protein, Membrane trafficking protein, Other
01
Overview
Golgi SNAP receptor complex member 1 (GOSR1) is a membrane trafficking protein essential for transporting proteins from the ER to the Golgi and between Golgi compartments. As a t-SNARE, it is a key component in vesicle fusion during protein transport within the secretory pathway. It also may play a protective role in neuronal cells against oxidative stress by regulating reactive oxygen species, mediated through p38 MAPK inhibition. GOSR1 is associated with rare congenital disorders of glycosylation and has been implicated in certain neurodegenerative processes, but it is not recognized as a classical drug target or therapeutic receptor in current pharmacological practice[1][2][3][4][5].
- Other names
- GOS-28GS28membrinGOSR1_HUMAN[1][5][6]
02
Biological functions
Protein transport between endoplasmic reticulum (ER) and Golgi apparatusIntra-Golgi transportVesicle docking and fusionCellular response to oxidative stress[1][2][5]
03
Disease associations
Congenital disorder of glycosylation, type IIGCongenital disorder of glycosylation, type IIHPossible roles in neurodegenerative disorders[1][3][4]
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