Golgin, RAB6-interacting (GORAB)

Golgin, RAB6-interacting (GORAB) is a member of the golgin family of coiled-coil proteins that localize to the Golgi apparatus and are crucial for proper Golgi structure and vesicle tethering[2][3]. GORAB interacts with the small GTPase RAB6, mediating its association with the trans-Golgi network, and also binds to Sas6 to facilitate proper centriole duplication, indicating dual roles in both Golgi and centriole function[2]. Mutations in GORAB are causative of gerodermia osteodysplastica, a genetic disorder characterized by connective tissue abnormalities[2][4]. Although GORAB participates in key structural and organizational aspects of intracellular trafficking and organelle architecture, it is not currently considered a druggable or therapeutic target such as a receptor or enzyme, and thus has no known interacting drugs or drug mechanisms[2][3][4].

Other names

SCYL1BP1RAB6-interacting golgin proteinGerodermia osteodysplastica protein