Golgin A8 family member A (GOLGA8A)

Golgin A8 family member A (GOLGA8A) is a Golgi matrix protein encoded by the GOLGA8A gene in humans[1]. It is one of several golgins—a family of proteins that localize to the Golgi apparatus and are essential for maintaining its integrity, structure, and function. Golgins help facilitate vesicle tethering, ensuring efficient protein sorting and trafficking through the Golgi network, and are involved in interactions with microtubules, especially during cell division[1][2][3]. GOLGA8A shows substantial structural similarity to other family members, notably GOLGA2, and is one of many highly similar copies on human chromosome 15—gene duplication and alternative splicing further contribute to isoform diversity[1][2]. GOLGA8A itself is not currently regarded as a therapeutic target, clinical biomarker, or the direct cause of any disorder, but the integrity of Golgi matrix proteins is essential for proper cell secretory pathway function and cell survival[2][3][4]. Researchers continue to explore the broader roles of Golgi proteins in disease, with special interest in cancer, but no drugs or clinical interventions specifically target GOLGA8A[4][6][8].

Other names

Golgin subfamily A member 8AGOLGA8AGM88GOLGA8BKIAA0855GOLGIN-67FAP286CFAP28688 kDa Golgi matrix proteinGM88 autoantigen