Target intelligence / Profile preview

Golgin A8 family member H (GOLGA8H)

Target
GOLGA8H
Molecular classification
Other (Golgi matrix protein, golgin family)
01

Overview

Golgin A8 family member H (GOLGA8H) is a predicted protein coding gene belonging to the golgin family, which consists of coiled-coil proteins that function as structural components of the Golgi apparatus. GOLGA8H is predicted to be involved in the organization of Golgi structure and is localized to the Golgi cisterna and Golgi cisterna membrane, particularly the cis-Golgi network[3]. Unlike enzymes, ion channels, or receptors, golgins are primarily structural and scaffolding proteins involved in organizing Golgi membranes and maintaining organelle architecture; they are not recognized as direct therapeutic drug targets. Current knowledge does not indicate a direct role in pharmacological targeting, biomarker development, or interaction with drugs, though mutations or dysregulation may be associated with certain congenital heart disorders[3].

Other names
Golgin subfamily A member 8HGOLGA6L11Golgin subfamily A member 8-like protein 1Golgi autoantigengolgin subfamily a 6-like 11GOLGA8H
02

Biological functions

Golgi organization
03

Disease associations

Other (associated with congenital heart malformations including tricuspid atresia and right atrial isomerism[3])

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