Golgin A8 family member O (GOLGA8O)

Golgin A8 family member O (GOLGA8O) encodes a long coiled-coil protein that is highly homologous to other members of the GOLGA8 subfamily, with >99% sequence identity between paralogs[1][3]. The protein localizes predominantly to the trans-Golgi apparatus and the inner leaflet of the plasma membrane, where it tethers vesicles and contributes to Golgi structural integrity[1][3][7]. GOLGA8O and related duplicons represent a human-specific, highly duplicated gene family in a genetically unstable region of chromosome 15[1]. Recent research suggests GOLGA8O expression enhances the productive uptake and intracellular availability of antisense oligonucleotides by promoting their escape from endocytic compartments and facilitating their movement within the cell; however, GOLGA8O itself is not a conventional drug target, and further studies are required to fully elucidate its biological and therapeutic relevance[1][3][7].

Other names

Golgin subfamily A member 8OGOLGA8OGolgin subfamily A member 6-like protein 11