Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Golgin subfamily A member 2 (GM130)
- Target
- GM130
- Molecular classification
- Golgi matrix protein, Peripheral membrane protein, Other (membrane skeleton protein)
01
Overview
GM130 (Golgin subfamily A member 2) is a peripheral membrane protein localized to the cis-Golgi stack. It functions as a membrane skeleton component that maintains Golgi apparatus structure, facilitates vesicular trafficking, and links the Golgi organelle to the microtubule cytoskeleton, contributing to cell polarity and division. GM130 is ubiquitously expressed and essential for normal protein glycosylation and sorting. Mutations in the encoding gene, GOLGA2, can result in severe neuromuscular disorders including developmental delay, progressive microcephaly, congenital muscular dystrophy, and abnormal glycosylation[6][1][3][2]. There are no approved drugs or therapies directly targeting GM130, and its deficiency is associated with incompatible cellular phenotypes.
- Other names
- Golgin subfamily A member 2GM130GOLGA2Golgi matrix protein 130
02
Biological functions
Maintenance of Golgi apparatus structure (Golgi stack skeleton)Microtubule cytoskeleton organizationPositive regulation of protein glycosylationVesicular traffickingCellular polarityCell division
03
Disease associations
Neuromuscular disorders (including congenital muscular dystrophy and microcephaly)Congenital disorders of glycosylationOther (disruption linked to developmental delay, seizures, and possibly muscle/brain dysfunction)
Beyond the preview
Go deeper on Golgin subfamily A member 2 (GM130).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Golgin subfamily A member 2 (GM130).