Golgin subfamily A member 3 (GOLGA3)

Golgin subfamily A member 3 (GOLGA3) is a coiled-coil protein that localizes to the Golgi apparatus—the cellular organelle responsible for protein and lipid glycosylation and trafficking in the secretory pathway[1][2][7]. GOLGA3 is implicated in maintaining the structural integrity of the Golgi, participating in nuclear transport, and ensuring proper protein sorting through Golgi-microtubule interactions, particularly during cell division[1][2][7]. In mouse models, loss of GOLGA3 function disrupts spermatogenesis and leads to male infertility, with identified roles in protein trafficking, apoptosis, and Golgi positioning in germ cells[4][8]. Although associated with certain diseases as a gene (such as primary ciliary dyskinesia), GOLGA3 is not itself considered a classic therapeutic target like a receptor or enzyme, and no drugs currently interact directly with it[2]. Several transcript variants and isoforms of GOLGA3 exist, but its full biological roles and disease implications continue to be actively researched[1][2][4].

Other names

Golgin-160GCP170MEA-2Golgi complex-associated protein of 170 kDaGolgi autoantigenSY2/SY10 proteinGolgi peripheral membrane proteingolgin-165male enhanced antigen-2Golgi membrane associated protein