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Golgin subfamily A member 5 (GOLGA5)
- Target
- GOLGA5
- Molecular classification
- Other (Golgi matrix protein; golgin family member)
01
Overview
Golgin subfamily A member 5 (GOLGA5) is a coiled-coil membrane protein and a member of the golgin family that localizes to the Golgi apparatus, an organelle central to the glycosylation and transport of proteins and lipids. GOLGA5 is involved in the maintenance of Golgi structure, specifically stimulating the formation of Golgi stacks and ribbons, and plays a role in intra-Golgi retrograde transport and vesicle tethering/docking. Chromosomal translocations involving GOLGA5 and the RET proto-oncogene have been identified in certain tumor tissues, where chimeric fusions (e.g., RET-II) are linked to thyroid cancer. There is currently no evidence that GOLGA5 itself is a therapeutic drug target, biomarker, or associated with notable drug safety concerns.
- Other names
- Golgin-84GOLIM5Protein Ret-IIRET-fused gene 5 proteincell proliferation-inducing gene 31 proteinrfg5PIG31Ret-IIgolgi integral membrane protein 5golgi autoantigengolgi subfamily A5
02
Biological functions
Maintains Golgi structureStimulates formation of Golgi stacks and ribbonsInvolved in intra-Golgi retrograde transportVesicle tethering and docking
03
Disease associations
Cancer (as part of gene fusions in thyroid carcinoma with RET)Congenital disorder of glycosylationThyroid cancer, nonmedullary
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