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Golgin subfamily A member 7 (GOLGA7)
- Target
- GOLGA7
- Molecular classification
- Other (acylated Golgi-associated protein), Component of palmitoyltransferase complex
01
Overview
Golgin subfamily A member 7 (GOLGA7) is an acylated protein encoded by the GOLGA7 gene, localized in the Golgi apparatus where it participates in the transport of proteins from the Golgi to the plasma membrane, and is a component of the ZDHHC9 palmitoyltransferase complex responsible for S-palmitoylation of specific target proteins such as HRAS and NRAS[1][4][6][7]. GOLGA7 additionally acts as an accessory protein in complexes that can mediate specific forms of non-apoptotic cell death in response to small molecules in certain contexts such as cancer cell models[2]. There are no approved drugs directly targeting this protein, and it is not currently recognized as a canonical therapeutic target.
- Other names
- Golgin A7GCP16GOLGA3AP1GOLGA7AHSPC041Golgi complex-associated protein of 16 kDagolgi autoantigenHDCKB03P
02
Mechanism of action
Not applicable (no approved/known drugs interacting directly with GOLGA7)
03
Biological functions
Protein transport from Golgi to plasma membranePeptidyl-L-cysteine S-palmitoylationProtein stabilization
04
Disease associations
Other (Potential role in cancer cell death^CIL56, but not clearly established as a disease driver)
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