Target intelligence / Profile preview

Gonadotrophin-Releasing Hormone Receptor (GnRHR)

Target: GnRHR
Molecular classification: G protein-coupled receptor (GPCR), Seven-transmembrane domain receptor, Class A GPCR, Rhodopsin-like GPCR

Overview

The Gonadotrophin-Releasing Hormone Receptor (GnRHR) is a seven-transmembrane domain G protein-coupled receptor that mediates the effects of gonadotropin-releasing hormone (GnRH). It is primarily expressed on pituitary gonadotrope cells and plays a central role in regulating reproductive function by stimulating the synthesis and secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). GnRHR is a therapeutic target for reproductive disorders and hormone-dependent cancers.

Other names: Luteinizing hormone releasing hormone receptorLHRHRLRHRGNRHR1GRHRHH7

Mechanism of action

Agonists stimulate LH/FSH release when given intermittently; Antagonists/inhibitors suppress gonadal steroidogenesis when given continuously.

Biological functions

Signal transductionRegulation of luteinizing hormone (LH) secretionRegulation of follicle-stimulating hormone (FSH) secretionReproductive function

Disease associations

Hypogonadotropic hypogonadismCancer (breast, prostate, ovary)

Safety considerations

Continuous exposure to GnRH agonists suppresses LH/FSH release.Potential side effects associated with hormone manipulation.

Interacting drugs

GnRH agonists

2 more in the full profile.

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