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Target intelligence / Profile preview
HIV Envelope Glycoprotein gp120 (gp120)
- Target
- gp120
- Molecular classification
- Glycoprotein, Viral Envelope Protein
01
Overview
gp120 is a glycoprotein exposed on the surface of the HIV envelope, essential for virus entry into host cells. It binds to CD4 receptors and chemokine co-receptors CCR5 or CXCR4 on host cells, initiating the membrane fusion process. The extensive glycan shield and sequence variability contribute to immune evasion, making it a challenging target for therapeutic intervention.
- Other names
- Glycoprotein 120HIV-1 gp120gp120 subunit
02
Mechanism of action
Blocking viral entry by interfering with gp120 binding to CD4 or co-receptors (CCR5/CXCR4)
03
Biological functions
Viral entryReceptor binding (CD4, CCR5, CXCR4)Immune evasionMembrane fusion
04
Disease associations
HIV infectionAIDS pathogenesis
05
Safety considerations
High sequence variabilityExtensive glycosylation (glycan shield)Conformational flexibilityChallenges in eliciting broadly neutralizing antibodies
06
Interacting drugs
Entry inhibitors
1 more in the full profile.
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