GPCRs and other protein targets

The entry "GPCRs and other protein targets" refers collectively to G protein-coupled receptors and additional categories of druggable proteins, such as ion channels, kinases, nuclear hormone receptors, enzymes, and transporters. GPCRs themselves form the largest and arguably most important superfamily of membrane receptors in humans, with more than 800 members regulating diverse physiological and pathological processes. They are prime therapeutic targets, involved in diseases such as hypertension, pain, diabetes, obesity, Alzheimer's disease, and others. However, the phrase is too broad and nonspecific to uniquely define a single molecular entity suitable as a database target entry. It encompasses numerous gene and protein families with distinct structural and functional features, ligand types, and clinical importance[1][2][5].