GPI transamidase component PIG-T (PIGT)

GPI transamidase component PIG-T (PIGT) is an essential type-I transmembrane protein that forms part of the GPI transamidase enzyme complex in the endoplasmic reticulum. This complex catalyzes the posttranslational attachment of glycosylphosphatidylinositol (GPI) anchors to a wide variety of cell surface proteins, a process required for their proper localization and function. PIG-T specifically stabilizes and maintains the multi-protein complex by associating with other subunits, ensuring correct assembly for GPI anchor transfer. Mutations in the PIGT gene underlie severe congenital disorders affecting blood, nerve, and immune cells, including rare forms of paroxysmal nocturnal hemoglobinuria and congenital disorders of glycosylation. No known drugs directly target this molecule; its essential role is structural and regulatory in protein complex formation rather than being a direct therapeutic target.

Other names

phosphatidylinositol glycan anchor biosynthesis class TGPI-anchor transamidase component PIGTCGI-06PSEC0163UNQ716/PRO1379PIG-TPhosphatidylinositol-glycan biosynthesis class T proteinGPI transamidase subunitneurotrophin-regulated neuronal development-associated proteinMCAHS3NDAPPNH2