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Target intelligence / Profile preview
GPRC5D antisense RNA 1 (GPRC5D-AS1)
- Target
- GPRC5D-AS1
- Molecular classification
- Long non-coding RNA, Antisense RNA, Other
01
Overview
GPRC5D antisense RNA 1 (GPRC5D-AS1) is a long non-coding RNA transcribed from the antisense strand of the GPRC5D locus, and also associated with HEBP1[1][3]. It is located on human chromosome 12p13.1. In cancer contexts, particularly renal cell carcinoma, GPRC5D-AS1 functions as a tumor suppressor: downregulation of GPRC5D-AS1 results in increased proliferation, invasion, and migration of cancer cells, possibly by activating the Wnt-β-catenin signaling pathway and epithelial-mesenchymal transition. In sarcopenia, GPRC5D-AS1 regulates muscle cell ferroptosis through direct interaction with and upregulation of SLC7A11, reducing cellular iron-induced lipid peroxidation and cell death. Collectively, GPRC5D-AS1 is emerging as a disease-specific biomarker and potential therapeutic target, though its non-coding RNA nature presents unique targeting and validation challenges[1][3].
- Other names
- RP11-392P7.6GPRC5D-AS1HEBP1 antisense RNA 1
02
Mechanism of action
Modulates gene expression by interacting with mRNA and proteins (notably SLC7A11), Suppresses Wnt-β-catenin pathway, Inhibits ferroptosis via upregulation of SLC7A11
03
Biological functions
Tumor suppressionRegulation of cell proliferationRegulation of cell migrationRegulation of ferroptosisRegulation of invasionModulation of Wnt-β-catenin signalingRegulation of SLC7A11 expression
04
Disease associations
CancerSarcopeniaPotential biomarker for clinical prognosis
05
Safety considerations
No direct safety or toxicity concerns reported; therapeutic challenges include limited tissue validation and lack of druggability data
06
Biomarkers
Potential biomarker for renal cell carcinomaPotential biomarker for lung squamous cell carcinomaClinical association in sarcopenia
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