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GRAM domain containing 4 pseudogene 4 (GRAMD4P4)

Target
GRAMD4P4
Molecular classification
Pseudogene, Non-coding RNA locus (potentially, if transcribed)
01

Overview

GRAMD4P4 (GRAM domain containing 4 pseudogene 4) is a pseudogene, a segment of DNA that resembles a functional gene but generally does not encode a functional protein due to disabling mutations or lack of transcription[3][6]. Pseudogenes can sometimes have regulatory functions, such as affecting the expression of related genes by acting as competing endogenous RNA, modulating stability through sequence similarity, or altering small RNA (e.g., siRNA) pools[5][7]. However, GRAMD4P4 itself is not classified as a receptor, enzyme, transporter, or other canonical drug target, and there are currently no established or reported roles for this pseudogene in human disease or therapy[3][6]. It retains a gene identifier in genomic databases (e.g., NCBI Gene 106480248)[3], but is primarily annotated as a nonfunctional genomic element. If you require structured data extractions, the above details can be mapped to the fields you provided. This entry should generally be flagged as non-target and likely as not useful for typical pharmacological or therapeutic targeting tasks.

Other names
GRAMD4P4
02

Mechanism of action

Not applicable

03

Biological functions

Possible regulatory function at the RNA level, such as miRNA decoy or modulation of related gene expression, as observed for other pseudogenes[5][7]No established protein function
04

Disease associations

Pseudogenes have been shown in some cases to modulate disease pathways via regulation of their protein-coding homologs or through ceRNA (competing endogenous RNA) networks; however, there is no direct evidence linking GRAMD4P4 specifically to diseases or disease-modifying functions[3]“Other” (can potentially have a disease role as a regulatory RNA, but this is unproven for GRAMD4P4)

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