Target intelligence / Profile preview

Gram-negative Bacteria

Molecular classification: Bacteria, Gram-negative organisms

Overview

Gram-negative bacteria are a major group of bacteria characterized by their unique cell envelope structure, including an inner membrane, a thin peptidoglycan layer, and an outer membrane containing lipopolysaccharides (LPS). Many species are pathogenic, causing a variety of diseases. Their double-membrane system contributes to intrinsic antibiotic resistance, and LPS can trigger strong immune responses. Key structural components like porins and the periplasm are also potential therapeutic targets.

Mechanism of action

Inhibition of peptidoglycan synthesis, disruption of membranes, interference with cell wall biosynthesis

Biological functions

PathogenesisNutrient processingDefenseImmune response modulation

Disease associations

GastroenteritisPneumoniaUrinary Tract InfectionsBloodstream InfectionsWound InfectionsMeningitis

Safety considerations

Endotoxin release (LPS)Antibiotic resistance

Interacting drugs

Penicillins

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