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Target intelligence / Profile preview
Gram-Positive Bacteria at Lower Esophageal Sphincter (N/A)
- Target
- N/A
- Molecular classification
- Microbiota, Bacteria
01
Overview
Gram-positive bacteria are a major component of the normal esophageal microbiota, especially in healthy individuals at the lower esophageal sphincter (LES). They contribute to maintenance of epithelial barrier integrity, production of antibacterial substances, and modulation of local immune responses. Genera include *Streptococcus*, *Lactobacillus*, and Actinobacteria. A shift towards gram-negative dominance at the LES is associated with GERD and Barrett's Esophagus.
- Other names
- Esophageal Gram-Positive FloraLES Gram-Positive MicrobiotaLower Esophageal Sphincter Gram-Positive Bacteria
02
Mechanism of action
N/A
03
Biological functions
Maintenance of epithelial barrier integrityProduction of antibacterial substancesModulation of local immune responsesHomeostasis maintenance
04
Disease associations
Gastroesophageal Reflux Disease (GERD)Barrett's EsophagusInflammationDysbiosis
05
Safety considerations
Potential for dysbiosisShift towards gram-negative dominance
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