Granulation tissue formation pathway

Granulation tissue formation is a critical phase of the wound healing process, characterized by the proliferation of fibroblasts, keratinocytes, endothelial cells, and the development of new capillaries within an extracellular matrix primarily composed of type III collagen[1][2][4]. This phase facilitates wound closure by generating a vascularized and cellular scaffold that fills tissue defects, supports re-epithelialization, and is eventually remodeled into scar tissue[1][2]. The process is regulated by growth factors such as TGF-β, VEGF, and PDGF, and can be disrupted by infection, foreign material, or systemic disease, leading to either chronic wounds or hypertrophic scarring[2][3][4]. As a pathway, it is not a single molecular drug target, but a dynamic interplay of several cell types and signaling molecules[2][3][5].

Other names

Granulation tissue formationWound granulation processGranulation phase of wound healing