Target intelligence / Profile preview

Granulin Precursor Protein (PGRN)

Target: PGRN
Molecular classification: Glycoprotein, Secreted protein, Growth factor precursor

Overview

The granulin precursor protein (progranulin) is a secreted glycoprotein that plays diverse roles in cell growth, wound healing, inflammation, lysosomal function, and neuronal survival. It is the precursor for granulins, a family of smaller peptides generated by proteolytic cleavage. Mutations or deficiencies in progranulin are associated with frontotemporal lobar degeneration (FTLD), neuronal ceroid lipofuscinosis and Lupus nephritis. It acts both extracellularly via signal transduction pathways and intracellularly via transcriptional modulation. It's involved in normal lysosome function, and deficiency impairs cellular waste processing.

Other names: GEP (Granulin/Epithelin Precursor)GP88PCDGF (PC cell-derived growth factor)PEPIProepithelinCLN11

Biological functions

Cell growth regulationCell divisionCell survivalWound healingInflammation modulationLysosomal functionNeuronal survival

Disease associations

Frontotemporal lobar degeneration (FTLD)Neuronal ceroid lipofuscinosisLupus nephritis

Safety considerations

The balance between full-length progranulin and cleaved granulins is crucial, and altering this balance could have unintended consequences.Overexpression could potentially promote tumor growth due to its role in cell proliferation.Modulation of inflammation needs to be carefully controlled due to the opposing roles of progranulin and granulins.

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