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Target intelligence / Profile preview
Granulocyte colony-stimulating factor receptor
- Molecular classification
- Receptor, Cytokine Receptor
01
Overview
The granulocyte colony-stimulating factor receptor (G-CSFR), also known as CSF3R, is a cell surface receptor primarily expressed on precursor cells in the bone marrow. It mediates the effects of its ligand, granulocyte colony-stimulating factor (G-CSF), to stimulate proliferation and differentiation of myeloid progenitors into mature neutrophilic granulocytes and macrophages. Upon activation by G-CSF, G-CSFR initiates multiple intracellular signaling cascades, including JAK/STAT, PI3K-AKT, and RAS-MAPK pathways.
- Other names
- G-CSFRCSF3R
02
Mechanism of action
Recombinant human G-CSF binds to the G-CSFR, stimulating proliferation and differentiation of myeloid progenitors into mature neutrophils.
03
Biological functions
Signal transductionCell proliferationCell differentiationHematopoiesisImmune response
04
Disease associations
NeutropeniaSevere Congenital NeutropeniaLeukemia
05
Safety considerations
Potential for excessive neutrophil productionRisk of splenic ruptureAntibody development against recombinant G-CSF
06
Interacting drugs
Recombinant human G-CSF (e.g., Filgrastim, Pegfilgrastim)
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