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Target intelligence / Profile preview
Granulocyte-macrophage colony-stimulating factor receptor (GM-CSF receptor)
- Target
- GM-CSF receptor
- Molecular classification
- Receptor, Cytokine Receptor, Type I transmembrane protein, Heterodimer
01
Overview
The granulocyte-macrophage colony-stimulating factor receptor is an essential heterodimeric cytokine receptor regulating key aspects of innate immunity through control over myeloid lineage development/functionality while also playing broader roles across immune regulation/inflammation/homeostasis beyond classical hematopoiesis.
- Other names
- CD116
02
Mechanism of action
Targeting either GM-CSF or its receptor
03
Biological functions
Signal transductionHematopoiesisMyeloid cell proliferationMyeloid cell differentiationMyeloid cell maturationMyeloid cell survivalImmune responseDendritic cell developmentPulmonary homeostasisModulation of inflammationEpithelial cell proliferation/repair
04
Disease associations
Hematologic malignanciesLeukemiaMyeloproliferative disordersInflammatory diseasesAutoimmune diseasesRheumatoid arthritisPulmonary alveolar proteinosisAllergic diseases
05
Safety considerations
Overactivation can drive harmful inflammationAberrant signaling contributes to uncontrolled proliferation/survival signals
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