Granulocyte-macrophage colony-stimulating factor receptor (GM-CSF receptor) (GM-CSFR)

The granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR) is a type I transmembrane cytokine receptor comprised of an α subunit (CD116) which binds the GM-CSF ligand, and a βc (common) subunit which transduces intracellular signaling. Receptor activation leads to phosphorylation events that recruit and activate downstream signaling proteins, including JAK2, STAT5, ERK, and PI3K, orchestrating cell survival, proliferation, and differentiation. GM-CSFR plays a central role in hematopoiesis, immune regulation, and inflammatory responses, and is implicated in various diseases including inflammatory disorders, autoimmune diseases, cancers of myeloid origin, and some neurodegenerative conditions. Drugs targeting this receptor, including agonists and antagonists, are used or under investigation for a range of hematologic and immune-mediated conditions.

Other names

CSF2 receptorGM-CSF receptor alpha and beta subunitsColony-stimulating factor 2 receptorCD116 (alpha subunit)Beta common receptor (shared βc subunit with IL-3 and IL-5 receptors)

Cytokine binding induces receptor dimerization/multimerization and activation Triggering of JAK2/STAT5, MAPK, PI3K, and NF-κB signaling pathways Modulation of immune cell survival, proliferation, differentiation, and activation