Granulocyte-macrophage colony-stimulating factor receptor beta subunit

The granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR) beta subunit (βc or CD131) is a critical component of the GM-CSFR complex, which mediates the effects of GM-CSF on myeloid cells. It is essential for high-affinity ligand binding and signal transduction. As a shared subunit for IL-3 and IL-5 receptors, it represents an attractive therapeutic target for modulating immune responses in diseases involving dysregulated myelopoiesis or inflammation. Activation of this receptor leads to JAK/STAT signaling and influences myeloid cell proliferation, differentiation, and survival. Downregulation mechanisms include SHP‑1/SOCS-mediated inhibition, degradation, and internalization. Mutations affecting this receptor can lead to constitutive activation and dysregulation, implicated in disease pathogenesis, including leukemias.

Other names

βcCD131Common beta chainβ common

Modulation of cytokine signaling via receptor blockade or inhibition of downstream signaling pathways (e.g., JAK/STAT)