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Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA)
- Target
- CSF2RA
- Molecular classification
- Cytokine receptor, Receptor
01
Overview
The granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA) is the alpha component of the heterodimeric receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine that regulates the production, differentiation, and function of granulocytes and macrophages. This protein is a member of the cytokine receptor family and is also known as CD116. Upon ligand binding, it heterodimerizes with the beta chain (CD131/CSF2RB) and activates downstream signaling pathways, primarily the JAK/STAT pathway. Mutations or dysfunctions are associated with surfactant metabolism dysfunction type 4 and hereditary pulmonary alveolar proteinosis.
- Other names
- Colony Stimulating Factor 2 Receptor Subunit AlphaGM-CSF-R-AlphaCD116 AntigenGMR-AlphaCSF2RYSMDP4
02
Biological functions
Signal transductionHematopoiesis regulationCell proliferationCell differentiationImmune responseCell activation
03
Disease associations
Surfactant metabolism dysfunction type 4Hereditary pulmonary alveolar proteinosis
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