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Granulocytes (N/A)

Target: N/A
Molecular classification: White Blood Cells, Leukocytes

Overview

Granulocytes are a category of white blood cells characterized by the presence of numerous granules in their cytoplasm. These granules contain enzymes and other proteins crucial for immune defense, particularly in fighting infections and mediating inflammation. They are part of the innate immune system, providing rapid responses to pathogens. The main types are neutrophils, eosinophils, and basophils. Their functions include phagocytosis, degranulation (releasing toxic substances), and modulation of inflammation. Abnormal granulocyte levels or function can contribute to various diseases.

Other names: Polymorphonuclear leukocytes (PMNs)NeutrophilsEosinophilsBasophils

Mechanism of action

N/A

Biological functions

Innate ImmunityPhagocytosisDegranulationInflammationDefense against bacteriaDefense against fungiDefense against parasitesCytokine productionChemotaxis

Disease associations

InfectionInflammationAllergyAsthmaAutoimmunityCancer (indirectly)

Safety considerations

Granulocytopenia leading to increased risk of infectionDysregulated granulocyte activity leading to chronic inflammationNeutrophilic inflammation contributing to tissue damageEosinophilic inflammation contributing to allergic reactionsSide effects of drugs affecting granulocyte production or function

Interacting drugs

Corticosteroids

4 more in the full profile.

Biomarkers

Neutrophil countEosinophil countBasophil countMyeloperoxidase (MPO)Elastase

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