Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Granzyme B (GZMB)
- Target
- GZMB
- Molecular classification
- Serine Protease, Enzyme, Caspase-like serine protease
01
Overview
Granzyme B is a serine protease enzyme primarily found in cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. It plays a critical role in inducing apoptosis in target cells, contributing to immune defense against viral infections and tumors. Granzyme B initiates apoptosis by activating caspases, cleaving BID, and directly cleaving other substrates that impact apoptotic signaling and cellular proliferation. It also contributes to inflammation and tissue remodeling. Dysregulation of granzyme B is associated with various diseases, including transplant rejection, autoimmune disorders, and cancer.
02
Mechanism of action
Serine protease inhibitors (experimental)
03
Biological functions
ApoptosisCell deathImmune responseCytokine processingExtracellular matrix degradationInflammation
04
Disease associations
Transplant rejectionAutoimmune disordersChronic inflammatory diseasesTumor immune surveillance failureCancerFibrosis
05
Safety considerations
Potential for off-target effects due to broad substrate specificityRisk of disrupting immune homeostasisPotential for increased susceptibility to infections or cancer if activity is excessively inhibited
Beyond the preview
Go deeper on Granzyme B (GZMB).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Granzyme B (GZMB).