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Target intelligence / Profile preview
Granzyme B (GZMB)
- Target
- GZMB
- Molecular classification
- Serine Protease, Enzyme, Caspase-like serine protease
01
Overview
Granzyme B is a serine protease enzyme primarily found in cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. It plays a critical role in inducing apoptosis in target cells, contributing to immune defense against viral infections and tumors. Granzyme B initiates apoptosis by activating caspases, cleaving BID, and directly cleaving other substrates that impact apoptotic signaling and cellular proliferation. It also contributes to inflammation and tissue remodeling. Dysregulation of granzyme B is associated with various diseases, including transplant rejection, autoimmune disorders, and cancer.
02
Mechanism of action
Serine protease inhibitors (experimental)
03
Biological functions
ApoptosisCell deathImmune responseCytokine processingExtracellular matrix degradationInflammation
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Disease associations
Transplant rejectionAutoimmune disordersChronic inflammatory diseasesTumor immune surveillance failureCancerFibrosis
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Safety considerations
Potential for off-target effects due to broad substrate specificityRisk of disrupting immune homeostasisPotential for increased susceptibility to infections or cancer if activity is excessively inhibited
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