Grass Group 5 Allergen (Group 5 Allergen)

Grass Group 5 allergens are a family of highly potent and prevalent proteins found in the pollen of temperate grasses, such as timothy grass (*Phleum pratense*), ryegrass (*Lolium perenne*), and canary grass. These allergens are major triggers for allergic rhinitis (hay fever) and bronchial asthma, especially during the grass pollen season in temperate climates. They are characterized by ribonuclease activity and consist of isoforms such as Group 5a and Group 5b. Sensitization to Group 5 allergens is prevalent in a significant proportion of grass pollen-allergic individuals.

Other names

Phl p 5Lol p 5Pha a 5Group V allergenPhl p VPhl p Vb

Allergen immunotherapy aims to induce tolerance by repeated exposure to the allergen, shifting the immune response from Th2 to Th1 and increasing IgG4 antibody production.