Target intelligence / Profile preview

Grass Pollen Allergen B-cell Epitope (N/A)

Target
N/A
Molecular classification
Peptide, Epitope, Allergen
01

Overview

Grass Pollen Allergen B-cell Epitopes are specific regions within grass pollen allergens (e.g., Phl p 1) recognized by antibodies, primarily IgE and IgG. These epitopes play a central role in triggering allergic reactions and modulating immune responses during immunotherapy. They are targets for diagnostics and the development of safer allergy vaccines aimed at inducing protective antibody responses without eliciting unwanted T cell activation or increasing the risk of anaphylaxis.

Other names
Phl p 1 B-cell EpitopeGroup 1 Grass Pollen Allergen EpitopeTimothy Grass Allergen EpitopeGrass Pollen Allergen Determinant
02

Mechanism of action

BM32 induces blocking IgG antibodies against grass pollen allergens. Allergen immunotherapy aims to induce IgG4 antibodies that compete with IgE for binding to the allergen epitopes.

03

Biological functions

IgE bindingIgG bindingB-cell activationMast cell degranulationHistamine releaseAntibody productionImmune response modulation
04

Disease associations

Seasonal allergic rhinitisAllergic asthmaGrass pollen allergy
05

Safety considerations

Potential for anaphylaxis during immunotherapyUnwanted T cell activationRisk of boosting pathogenic IgE responses
06

Interacting drugs

BM32 (peptide vaccine)

1 more in the full profile.

07

Biomarkers

Phl p 1-specific IgE levelsPhl p 1-specific IgG4 levelsBasophil activation

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