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Grass pollen allergen epitopes are specific regions on grass pollen proteins recognized by the immune system, triggering IgE-mediated allergic responses. Major allergen groups include group 1 (e.g., Phl p 1), groups 2/3 (e.g., Phl p 2/Phl p 3), and group 5 (e.g., Phl p 5). These epitopes can be linear or conformational, with cross-reactivity occurring due to sequence homology among different grass species. Repeated exposure leads to increased IgE production and clinical sensitivity. Molecular weights range from ~6-60 kDa. The presence of multiple IgE binding sites per molecule contributes to their high allergenic potential.
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